NSD1 governs H3K36me2-mediated DNA methylation and drives differentiation of human iPSCs by regulating HIDEN lncRNA expression
Anna Hansknecht, Martina Mankarious, Monica Varona Baranda, Esra Dursun Torlak, Wolfgang Wagner, Kira Zeevaert, Deepika Puri
This study shows NSD1 regulates DNA methylation and endodermal differentiation of human iPSCs through HIDEN lncRNA, revealing a novel mechanism linked to Sotos syndrome.
bioRxiv · Jun 16, 2025 · PreprintCell Biology