Lactate and glycerol-3-phosphate metabolism cooperatively regulate growth and redox balance during Drosophila melanogaster larval development
Hongde Li, Kasun Buddika, Maria C. Sterrett, Cole R. Julick, Rose C. Pletcher, Chelsea J. Gosney, Anna K. Burton, Jonathan A. Karty, Kristi L. Montooth, Nicholas S. Sokol, Jason M. Tennessen
This study shows that dLDH is dispensable for larval growth but its absence is compensated by increased G3P production, which affects redox balance and interacts with GPDH1 to influence development.
bioRxiv · Jan 10, 2019 · PreprintDevelopmental Biology