Jason M. Tennessen

Spatial isotope tracing maps compartmentalized nutrient use across the adult fruit fly

This study maps spatial metabolic activity in adult fruit flies using isotope tracing and mass-spectrometry imaging, revealing compartmentalized nutrient use across tissues.

Tumour rewires host tryptophan metabolism to promote organism-wide immune suppression

This study shows that Pten-deficient Drosophila tumours reprogram host tryptophan metabolism to suppress immunity and promote tumour growth through the kynurenine pathway.

Structural modeling supports an interaction between the Drosophila Estrogen-Related Receptor and Sima/HIF-1α

The paper uses structural modeling to support an interaction between dERR and Sima/HIF-1α, identifying a conserved LXXLL motif as a binding site.

Drosophila melanogaster lactate dehydrogenase deficiency recapitulates the exercise intolerance of human glycogen storage disease type XI

This study shows that loss of lactate dehydrogenase in Drosophila causes exercise intolerance and diet-dependent lethality, mirroring human LDH-A deficiency symptoms.

Comparative metabolomics identifies recurrent age-associated pathway remodeling across species

This study identifies shared age-associated pathway remodeling across species using comparative metabolomics, highlighting lipid and nucleotide pathways as core features of aging.

Exposure to perfluorooctanoic acid accelerates Drosophila melanogaster juvenile development and disrupts mitochondrial metabolism

This study shows PFOA exposure accelerates Drosophila melanogaster juvenile development and disrupts mitochondrial metabolism, leading to increased sensitivity to environmental stress.

Conserved Molecular Responses to Arsenite Exposure in Drosophila melanogaster

This study identifies conserved molecular responses to arsenite exposure in Drosophila, revealing shared pathways with human arsenic-related diseases.

The intracellular symbiont Wolbachia alters Drosophila development and metabolism to buffer against nutritional stress

This study shows Wolbachia supports Drosophila development and buffers against nutritional stress by altering metabolism and gene expression.

New alleles of D-2-hydroxyglutarate dehydrogenase enable studies of oncometabolite function in Drosophila melanogaster

The paper generates two novel D2hgdh loss-of-function mutations in Drosophila to study D-2HG accumulation and its effects on development and metabolism.

NAD+ reduction in glutamatergic neurons triggers fatty acid catabolism and neuroinflammation in the brain, mitigated by SARM1 deletion

The paper shows that loss of NMNAT2 in glutamatergic neurons causes metabolic shifts and neurodegeneration, which are mitigated by SARM1 deletion.

The Drosophila Estrogen-Related Receptor promotes triglyceride storage within the larval fat body

This study investigates the role of dERR in regulating lipid metabolism in Drosophila larval fat body, showing it promotes TAG accumulation and interacts with dHNF4.

The alternative oxidase reconfigures the larval mitochondrial electron transport system to accelerate growth and development in Drosophila melanogaster

This study shows that AOX from Ciona intestinalis accelerates Drosophila larval growth and development by reconfiguring the mitochondrial ETS without increasing body heat.

Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster

This paper identifies Sima/Hif1 as a critical factor for establishing the larval glycolytic program in Drosophila, showing it works with dERR to regulate metabolism during development.

Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster

This study shows that L2hgdh in Drosophila renal tubules prevents L-2HG accumulation, supports mitochondrial metabolism, and enables hypoxia tolerance.

Glycolytic Disruption Triggers Interorgan Signaling to Nonautonomously Restrict Drosophila Larval Growth

The paper shows that disrupting glycolysis in Drosophila larvae leads to systemic cytokine signaling changes, nonautonomously restricting growth.

Exposure to the pesticide tefluthrin causes developmental neurotoxicity in zebrafish

This study shows tefluthrin exposure causes neurotoxicity in zebrafish larvae by inhibiting LPCAT3 and disrupting lipid metabolism.

Characterization of genetic and molecular tools for studying the endogenous expression of Lactate dehydrogenase in Drosophila melanogaster

The paper characterizes genetic and molecular tools for studying Ldh expression in Drosophila melanogaster and finds they reveal complex tissue-specific expression patterns.

Metabolomic analysis of Drosophila melanogaster larvae lacking Pyruvate kinase

This study investigates the metabolic effects of Pyruvate kinase (Pyk) loss in Drosophila larvae, revealing disrupted glycolysis and compensatory metabolic changes.

Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies

This paper investigates the effects of altering lactate metabolism in Drosophila neurons and glia on aging and memory, finding age-dependent impacts on survival and memory.

The Drosophila melanogaster enzyme glycerol-3-phosphate dehydrogenase 1 is required for oogenesis, embryonic development, and amino acid homeostasis

This study investigates the role of GPDH1 in Drosophila development, revealing its essential functions in oogenesis, embryogenesis, and metabolic homeostasis through genetic and metabolomics analyses.

NAD homeostasis maintained by NMNAT2 supports vesicular glycolysis and fuels fast axonal transport in distal axons of cortical glutamatergic neurons in mice

This study shows NMNAT2 maintains NAD redox potential in axons to support glycolysis and fast transport, preventing axonal degeneration in mice.

miR-125-chinmo pathway regulates dietary restriction dependent enhancement of lifespan in Drosophila

This study identifies miR-125 and its target chinmo as regulators of dietary restriction-induced lifespan extension in Drosophila, highlighting their role in fat metabolism and longevity.

The oncometabolite L-2-hydroxyglutarate is a common product of Dipteran larval development

The paper investigates L-2-hydroxyglutarate (L-2HG) accumulation in 18 insect species, finding high levels in Dipterans and suggesting a potential role in their development and pest control.

A genetic screen using the Drosophila melanogaster TRiP RNAi collection to identify metabolic enzymes required for eye development

The paper uses a Drosophila RNAi screen to identify metabolic enzymes involved in eye development, finding a role for glutamine and glutamate metabolism.

Lactate and glycerol-3-phosphate metabolism cooperatively regulate growth and redox balance during Drosophila melanogaster larval development

This study shows that dLDH is dispensable for larval growth but its absence is compensated by increased G3P production, which affects redox balance and interacts with GPDH1 to influence development.

The Drosophila mitochondrial citrate carrier regulates L-2-hydroxyglutarate accumulation by coupling the tricarboxylic acid cycle with glycolysis

This study investigates how the Drosophila mitochondrial citrate carrier affects L-2-hydroxyglutarate levels by linking the tricarboxylic acid cycle to glycolysis.