Kasun Buddika

Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster

This paper identifies Sima/Hif1 as a critical factor for establishing the larval glycolytic program in Drosophila, showing it works with dERR to regulate metabolism during development.

Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster

This study shows that L2hgdh in Drosophila renal tubules prevents L-2HG accumulation, supports mitochondrial metabolism, and enables hypoxia tolerance.

NULISA: a novel proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing

NULISA is a proteomic platform with attomolar sensitivity and high multiplexing, enabling detection of low-abundance proteins in liquid biopsies.

The RNA binding protein Swm is critical for Drosophila melanogaster intestinalprogenitor cell maintenance

This study shows that the RNA-binding protein Swm is essential for maintaining intestinal progenitor cell identity and function in Drosophila.

I-KCKT allows dissection-free RNA profiling of adult Drosophila intestinal progenitor cells

The paper introduces a dissection-free method to profile RNA-protein interactions in Drosophila intestinal progenitor cells using a GAL4 driver and UV cross-linked whole animal lysate, achieving high transcript capture with low background noise.

Lactate and glycerol-3-phosphate metabolism cooperatively regulate growth and redox balance during Drosophila melanogaster larval development

This study shows that dLDH is dispensable for larval growth but its absence is compensated by increased G3P production, which affects redox balance and interacts with GPDH1 to influence development.