Opposing lineage specifiers induce a pro-tumor hybrid-identity state in lung adenocarcinoma
Gabriela Fort, Henry Arnold, Soledad A. Camolotto, Kayla T. O’Toole, Rushmeen Tariq, Anna K. Waters, Katherine Gillis, Eric L. Snyder
This study identifies HNF4 as a driver of hybrid-identity states in KRAS-driven lung adenocarcinoma, showing that opposing lineage specifiers promote tumor progression and affect therapy response.
bioRxiv · Dec 2, 2024 · PreprintCancer Biology