Sex-specific plasticity mechanisms mediating fear extinction
Kourtney C. Graham, Justice Pomeroy-Tuck, Grace K O'Brien, Lacey K Webber, Anna L Drillen, Luke T. Coddington, Xinyu Zhao, Erik B. Bloss
The paper shows that male and female mice use different synaptic plasticity mechanisms for fear extinction, with males showing structural remodeling and GRIN2B dependence, while females do not.
bioRxiv · May 19, 2026 · PreprintNeuroscience