An inducible BRCA1 expression system with in vivo applicability uncovers activity of the combination of ATR and PARP inhibitors to overcome therapy resistance
Elsa Irving, Alaide Morcavallo, Jekaterina Vohhodina-Tretjakova, Paul W.G. Wijnhoven, Anna Louise Beckett, Michael P. Jacques, Rachel S Evans, Jennifer I. Moss, Anna Dominika Staniszewska, Josep V. Forment
This paper develops an inducible BRCA1 expression system to study hypomorphic variants and finds that combining ATR and PARP inhibitors overcomes resistance caused by BRCA1 {Delta}exon11 hypomorphs.
Cancers · Jan 20, 2026Peer-reviewedCancer Biology