Mapping the mammalian dark metabolome by in vivo isotope tracing
Michael Robert MacArthur, Justine Raeber, Wenyun Lu, Hantao Qiang, Amelia V. Schueppert, Lucas B. Ayres, Ricardo A. Cordova, Michael D. Neinast, Edmundo Leiva, Vanha N. Pham, Jenna E. AbuSalim, Connor S.R. Jankowski, Laith Z. Samarah, Asael Roichman, Christian G. Peace, , Michael A. Skinnider
The paper uses in vivo isotope tracing and AI to identify biosynthetic origins of unknown metabolites, revealing new metabolic pathways and age-related changes.
bioRxiv · Apr 2, 2026 · PreprintBiochemistry