Jenna E. AbuSalim

Mapping the mammalian dark metabolome by in vivo isotope tracing

The paper uses in vivo isotope tracing and AI to identify biosynthetic origins of unknown metabolites, revealing new metabolic pathways and age-related changes.

Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Boosting Fat Oxidation

SAAR improves exercise capacity in mice by enhancing fat oxidation and substrate availability through VEGF signaling and CD36-dependent fatty acid transport.

Many circulating indole and phenol metabolites are host derived

The paper shows that mammalian cells produce certain indole and phenol metabolites, while bacterial metabolism is required for others, highlighting host contributions to circulating pools.

Language model-guided anticipation and discovery of unknown metabolites

This paper introduces DeepMet, a chemical language model that predicts and discovers unknown metabolites using mass spectrometry data.