Wenyun Lu

This study shows that caloric restriction before tumor induction delays cancer cachexia by reducing systemic inflammation and preserving lean mass.

The paper uses in vivo isotope tracing and AI to identify biosynthetic origins of unknown metabolites, revealing new metabolic pathways and age-related changes.

SAAR improves exercise capacity in mice by enhancing fat oxidation and substrate availability through VEGF signaling and CD36-dependent fatty acid transport.

This study maps spatial metabolic gradients in murine liver and intestine using integrated experimental-computational methods, revealing distinct metabolic patterns and fructose-induced metabolic derangements.

This paper shows that combining dietary restriction of arginine and proline with polyamine depletion drugs enhances tumor differentiation and survival in a neuroblastoma mouse model by disrupting oncogenic translation.

This paper introduces DeepMet, a chemical language model that predicts and discovers unknown metabolites using mass spectrometry data.

The paper introduces NetID, a global network optimization method for annotating untargeted metabolomics data, identifying novel metabolites in yeast and mouse datasets.

This study quantifies metabolic fluxes of circulating metabolites in mice using isotope tracing and mass spectrometry to identify major metabolic cycles and their tissue-specific contributions.