Connor S.R. Jankowski

The paper uses in vivo isotope tracing and AI to identify biosynthetic origins of unknown metabolites, revealing new metabolic pathways and age-related changes.

This study maps spatial metabolic gradients in murine liver and intestine using integrated experimental-computational methods, revealing distinct metabolic patterns and fructose-induced metabolic derangements.

The paper identifies 2-hydroxymethylsuccinate as a product of itaconate metabolism via a CoA-independent pathway and shows tissue-specific degradation routes.