Author

Anna Mechel

Universitätsmedizin Göttingen

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Neuroscience· 1

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Approach:experimental assay· 1

Frequent Co-Authors

Björn TwellsieckiD· 1 shared C. Alexander BoeckeriD· 1 shared Erika L.F. HolzbauriD· 1 shared Jessica M. Grein· 1 shared Lennart Evers· 1 shared Maria‐Sol Cima‐OmoriiD· 1 shared Markus ZweckstetteriD· 1 shared Michel Fricke· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Björn TwellsieckORCID

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1 paper

Recent·Most cited

Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation

Michel Fricke, Anna Mechel, Lennart Evers, Björn Twellsieck, Jessica M. Grein, Maria‐Sol Cima‐Omori, Mohammed Al‐Azzani, Tiago F. Outeiro, Markus Zweckstetter, Erika L.F. Holzbaur, C. Alexander Boecker

This study shows that PPM1H knockout disrupts axonal autophagy and increases alpha-synuclein aggregation in neurons, linking LRRK2 hyperactivity to Parkinson disease pathology.

Cell Reports · May 21, 2026Peer-reviewedNeuroscience