Author

Björn Twellsieck

Universitätsmedizin GöttingenORCID 0009-0004-5131-8796Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

Frequent Co-Authors

Anna Mechel· 1 shared C. Alexander BoeckeriD· 1 shared Erika L.F. HolzbauriD· 1 shared Jessica M. Grein· 1 shared Lennart Evers· 1 shared Maria‐Sol Cima‐OmoriiD· 1 shared Markus ZweckstetteriD· 1 shared Michel Fricke· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Anna Mechel

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1 paper

Recent·Most cited

NeuroscienceCell ReportsPeer-reviewedMay 21, 2026

Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation

Michel Fricke, Anna Mechel, Lennart Evers…·C. Alexander Boecker

This study shows that PPM1H knockout disrupts axonal autophagy and increases alpha-synuclein aggregation in neurons, linking LRRK2 hyperactivity to Parkinson disease pathology.

1 citation

experimental assay

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