C. Alexander Boecker

This study investigates the interaction between LRRK1 and LRRK2, showing they modulate Rab7 activity and lysosomal exocytosis, with starvation reducing their interaction and impairing lysosomal homeostasis.

This study shows that PPM1H knockout disrupts axonal autophagy and increases alpha-synuclein aggregation in neurons, linking LRRK2 hyperactivity to Parkinson disease pathology.

The paper shows that LRRK2 mutations disrupt autophagosome transport in neurons by creating a tug-of-war between dynein and kinesin motors, contributing to Parkinson's disease pathogenesis.

The paper uses proteomics to compare autophagy cargos in two Parkinson disease mouse models, finding distinct adaptive pathways in PINK1 and LRRK2 models.