RNA interference mediates RNA toxicity with parent-of-origin effects in C. elegans expressing CTG repeats
Maya Braun, Shachar Shoshani, Joana Teixeira, Anna Mellul, Maya Miller, Zvi Granot, Sylvia E. J. Fischer, Susana M. D. A. Garcia, Yuval Tabach
This study shows that RNA interference in C. elegans mediates RNA toxicity from maternal CTG repeats, causing offspring phenotypes that can be rescued by disrupting the RNAi machinery.
bioRxiv · May 19, 2021 · PreprintMolecular Biology