Interactions between non-prion and prion domains of Rnq1 direct formation of amyloid vs liquid-like aggregates and create transmission barriers
Sangeun Park, Dania M. Maldonado, Michele L. Kadnar, Monica Andrade, Anna P Fomitchova, Susan Weiss Liebman, Irina L. Derkatch
This paper investigates how a mutation in the non-prion domain of Rnq1 affects prion transmission and aggregation properties, showing it creates barriers to prion propagation and promotes liquid-like droplet formation.
bioRxiv · Jan 14, 2025 · PreprintGenetics