Sangeun Park

This paper shows that deleting ASC1 in yeast reduces TDP-43 toxicity by enhancing autophagy, rather than through polysome sequestration, while FUS toxicity remains unaffected.

The paper investigates how a yeast model of inborn metabolism errors affects TDP-43 aggregation and toxicity, finding that it shifts aggregates toward an amyloid-like state while reducing toxicity.

This paper investigates how a mutation in the non-prion domain of Rnq1 affects prion transmission and aggregation properties, showing it creates barriers to prion propagation and promotes liquid-like droplet formation.

The paper shows that CREST toxicity in yeast and flies is reduced by PBP1/ATXN2 deletion, suggesting ATXN2 as a therapeutic target for ALS.