Targeting the APRIL-BAFF axis in IgA nephropathy: preclinical insights from influenza challenge and single-cell spatial profiling
Kirk J. Rowley, Vinay Singh, Anna Roberts, Katherine A Halley, Joshua Brand, Jacob Vinay Vikas Konakondla, Daved Fared, Michelle Lu, Brett L. Hurst, Wayne W. Hancock, Gregory J. Babcock, Luke N. Robinson
This study compares selective APRIL and dual APRIL/BAFF inhibition in mice and humans, finding that dual blockade more severely disrupts B-cell maturation and immune protection.
bioRxiv · May 6, 2026 · PreprintImmunology