Brett L. Hurst

This study compares selective APRIL and dual APRIL/BAFF inhibition in mice and humans, finding that dual blockade more severely disrupts B-cell maturation and immune protection.

The paper investigates structure-activity relationships of pleconaril analogues against EV-D68, identifying compounds with antiviral activity and favorable ADME properties.

This study identifies potent SARS-CoV-2 PLpro inhibitors using machine learning, showing efficacy in a mouse model of COVID-19.

In an image-based screen of 1,670 compounds in SARS-CoV-2-infected human renal epithelial cells, remdesivir was the only antiviral with strong efficacy; chloroquine and hydroxychloroquine showed no benefit.