PP2A methylesterase, PME-1, and PP2A methyltransferase, LCMT-1, control sensitivity to impairments caused by injury-related oligomeric tau
Sowmya N. Sundaresh, Edward W. Vogel, Christopher D. Hue, Hong Zhang, Anna Staniszewski, Hanna L. Berman, Zafar Gill, Kesava R. Asam, Siqi Liang, Liwei Shen, Madhumathi Gnanaprakash, Erica Acquarone, Antonio Masone, Mauro Fà, Nicholas M. Kanaan, , Russell E. Nicholls
The paper investigates how PP2A regulators LCMT-1 and PME-1 affect sensitivity to tau-induced impairments in models of neurodegenerative diseases.
Alzheimer s & Dementia · Dec 1, 2025Peer-reviewedNeuroscience