Author

Erica Acquarone

Columbia UniversityORCID 0000-0002-3266-8115Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ottavio ArancioiD· 4 shared Agnieszka StaniszewskiiD· 3 shared Mauro FàiD· 2 shared Andrea PaquolaiD· 1 shared Andrew F. TeichiD· 1 shared Anna Staniszewski· 1 shared Antonio MasoneiD· 1 shared Barclay MorrisoniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersNeuroscience

Ottavio ArancioORCID

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4 papers

Recent·Most cited

The Highly Selective 5-HT2B Receptor Antagonist MW073 Mitigates Aggressive Behavior in an Alzheimer Disease Mouse Model.

Erica Acquarone, Saktimayee Mira Roy, Agnieszka Staniszewski, Daniel Martin Watterson, Ottavio Arancio

This study shows that the 5-HT2B receptor antagonist MW073 reduces aggressive behavior in an Alzheimer's disease mouse model.

Cells · Feb 1, 2026Peer-reviewedNeuroscience

PP2A methylesterase, PME-1, and PP2A methyltransferase, LCMT-1, control sensitivity to impairments caused by injury-related oligomeric tau

Sowmya N. Sundaresh, Edward W. Vogel, Christopher D. Hue, Hong Zhang, Anna Staniszewski, Hanna L. Berman, Zafar Gill, Kesava R. Asam, Siqi Liang, Liwei Shen, Madhumathi Gnanaprakash, Erica Acquarone, Antonio Masone, Mauro Fà, Nicholas M. Kanaan, , Russell E. Nicholls

The paper investigates how PP2A regulators LCMT-1 and PME-1 affect sensitivity to tau-induced impairments in models of neurodegenerative diseases.

Alzheimer s & Dementia · Dec 1, 2025Peer-reviewedNeuroscience

Epigenetic Shifts Reveal Alzheimer's Origins after Sustained Picomolar Aβ Exposure

Andrea Paquola, Erica Acquarone, Agnieszka Staniszewski, Andrew F. Teich, Ottavio Arancio

The paper identifies epigenetic and gene expression changes in mice exposed to prolonged low-dose Aβ42, linking them to phases of memory enhancement, transition, and decline associated with Alzheimer's disease.

bioRxiv · Aug 12, 2025 · PreprintNeuroscience

Design and Synthesis of Potent First-in-Class Histones Acetyltransferase Modulators.

Elisa Zuccarello, Mattia Mori, Elisa Calcagno, Rosa Purgatorio, Yan Feng, Erica Acquarone, Yitshak I. Francis, Mauro Fà, Agnieszka Staniszewski, Elentina K. Argyrousi, Coleman D. Barry, Hong Zhang, Shi-Xian Deng, Donald W. Landry, Ottavio Arancio, Jole Fiorito

The paper designs and synthesizes new activators of the p300 histone acetyltransferase enzyme to treat neurodegenerative and cancer disorders.

bioRxiv · Mar 3, 2025 · PreprintBiochemistry