Steroid-based Tide Quencher 1 probes enable real-time mapping of novel non-canonical cholesterol sites on the M1 muscarinic receptor
Nikolai Chetverikov, Eszter Szánti‐Pintér, Jan Jurica, Mariia Vodolazhenko, Miloš Buděšı́nský, Václav Zima, Martin Svoboda, Eva Dolejší, Alena Randáková, Anna Urbankova, Ján Jakubík, Eva Kudová
This paper introduces TQ1 probes to map non-canonical cholesterol-binding sites on the M1 muscarinic receptor, showing improved quenching and binding specificity compared to Dabcyl.
bioRxiv · Apr 1, 2026 · PreprintPharmacology & Toxicology