Metabolic engineering of Escherichia coli to modulate hydrogen sulfide levels in the mammalian gut
Justin A. Hayes, Brent Buchinger, Anna W. Lunger, Tanvi Khanvilkar, William Gasparrini, Matthew T. Fernez, Madeleine Morrissette, Philip Strandwitz, Abigail N. Koppes, Ryan A. Koppes, Benjamin M. Woolston
This paper engineers Escherichia coli to produce or consume hydrogen sulfide in specific gut regions, demonstrating methods to increase and decrease H2S levels in mice.
bioRxiv · Jul 24, 2026 · PreprintSynthetic Biology