Ryan A. Koppes

Olfactory Mucosa-Derived Mesenchymal Stem Cells Differentiate Towards a Schwann Cell-Like Phenotype Towards Sourcing for Peripheral Nerve Regeneration

This study differentiates olfactory mucosa-derived mesenchymal stem cells into Schwann cell-like cells using conditioned media and growth factors, showing changes in morphology, gene expression, and functionality.

Metabolic engineering of Escherichia coli to modulate hydrogen sulfide levels in the mammalian gut

This paper engineers Escherichia coli to produce or consume hydrogen sulfide in specific gut regions, demonstrating methods to increase and decrease H2S levels in mice.

Automated culture and monitoring of a high-throughput human heart-on-a-chip

This study develops an automated high-throughput heart-on-a-chip system using iPSC-derived cardiomyocytes and GCaMP6f for monitoring, showing a temperature-dependent decrease in beat rate.

Design and fabrication of demountable 3D microphysiological systems for modeling barrier function and underlying tissue interactions

This paper introduces a low-cost, demountable organ-on-chip platform using thermoplastics and a cut-and-assemble method, enabling high-resolution imaging and multi-layer tissue culture.

Gel-Amin for improving signal propagation and extracellular recordings of cardiomyocytes in a 3D Microphysiological System

This paper introduces Gel-Amin, a hydrogel that enhances extracellular voltage recordings and signal propagation in 3D cardiac microphysiological systems.