Dissecting GPCR Selectivity: A complex interplay of various intracellular motifs determines G-protein binding and activation
Sina B. Kirchhofer, Volker Jelinek, Katharina Klingelhöfer, Anna-Lena Krett, Moritz Bünemann
This study investigates how intracellular motifs in Muscarinic receptors influence G-protein binding and activation, showing that selectivity arises from complex interactions rather than single motifs.
bioRxiv · Dec 15, 2025 · PreprintPharmacology & Toxicology