Efficiency and localisation of AURKA degradation by PROTACs is modulated by deubiquitinases UCHL5 and target-selective OTUD6A
Annabel Cardno, Karen Roberts, Catherine Lindon
This study identifies deubiquitinases UCHL5 and OTUD6A that modulate AURKA degradation by PROTACs, revealing target-specific and ligase-dependent mechanisms.
bioRxiv · Apr 23, 2025 · PreprintCell Biology