Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from aged hosts against antibody opsonized Streptococcus pneumoniae
Shaunna R. Simmons, Annabel Rivera, Elsa N. Bou Ghanem
This study shows that aged neutrophils have impaired antimicrobial activity against antibody-opsonized pneumococci due to imbalanced ERK1/2 activation, which can be improved by ERK1/2 inhibition.
bioRxiv · May 27, 2025 · PreprintImmunology