Elsa N. Bou Ghanem

CD73 controls neutrophil responsiveness to type I interferon impairing antibacterial responses during secondary pneumococcal pneumonia

This study identifies CD73 as a regulator of neutrophil responsiveness to type I interferon, which impairs antibacterial responses during secondary pneumococcal pneumonia following influenza A virus infection.

Neutrophils induce effective antibody responses to the pneumococcal conjugate vaccine by inhibiting regulatory T cells

This study shows that neutrophils suppress regulatory T cells to enhance antibody responses to the pneumococcal conjugate vaccine in mice and humans.

Host aging induces a senescent-like phenotype in neutrophils and altered transcriptional responses to Streptococcus pneumoniae

This study shows that aging leads to senescent-like neutrophils in mice, which have reduced antimicrobial function and altered transcriptional responses to Streptococcus pneumoniae.

Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from aged hosts against antibody opsonized Streptococcus pneumoniae

This study shows that aged neutrophils have impaired antimicrobial activity against antibody-opsonized pneumococci due to imbalanced ERK1/2 activation, which can be improved by ERK1/2 inhibition.

Adenosine 2B receptor signaling impairs vaccine-mediated protection against pneumococcal infection in young hosts by blunting neutrophil killing of antibody opsonized bacteria

This study shows that adenosine 2B receptor signaling impairs neutrophil killing of antibody-opsonized pneumococci in young vaccinated mice, reducing vaccine efficacy, but not in aged mice.

Sex-based difference in immune responses and efficacy of the pneumococcal conjugate vaccine

This study examines sex-based differences in immune responses to the pneumococcal conjugate vaccine in mice, finding males have reduced antibody production and vaccine efficacy compared to females.

Streptococcus pneumoniae infection of lung epithelial cells induces internalization of surface GPI-anchored proteins through pneumolysin-mediated activation of host Rho GTPases

This study shows that pneumolysin from Streptococcus pneumoniae causes internalization of GPI-anchored proteins in lung epithelial cells via Rho GTPase activation, reducing cell death and membrane damage.