Modeling Endothelial Dysfunction in Idiopathic Pulmonary Fibrosis: Bridging Mechanistic Insights and Translational Applications
Annalena Branz, Irina Shalashova, Anastasia M. Funk, Tarek Gensheimer, Agnieszka Wytyk, Susanne L. Wespel, Jochen Drescher, Christoph H. Mayr, Lavinia Neubert, Jan C. Kamp, Mark Kühnel, Danny David Jonigk, Manfred Frick, Muriel Lizé
This paper identifies PMVEC alterations in IPF using single-cell RNA sequencing and spatial transcriptomics, develops endothelial injury models, and validates functional assays for drug discovery.
bioRxiv · Sep 29, 2025 · PreprintCell Biology