Author

Manfred Frick

Universität UlmORCID 0000-0002-4763-1104Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:spatial transcriptomics· 2 Approach:deep learning· 1

Frequent Co-Authors

Giorgio FoisiD· 3 shared Jan LawrenziD· 3 shared Jan MünchiD· 3 shared Annelies StevaertiD· 2 shared Lieve M. J. NaesensiD· 2 shared Rayhane NchiouaiD· 2 shared Agnieszka Wytyk· 1 shared Alexander KlegeriD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

Giorgio FoisORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

APP and APLP2 Kunitz Domains Are Potent Endogenous Inhibitors of TMPRSS2 and Respiratory Virus Infection

Jan Lawrenz, Shreyans Chatterjee, Armando Rodríguez Alfonso, Annelies Stevaert, Rayhane Nchioua, Gina-Marie Templin, Giorgio Fois, Manfred Frick, Lieve M. J. Naesens, Rüdiger Groß, Jan Münch

bioRxiv · Aug 18, 2026 · PreprintMicrobiology

Tonic interferons defend against respiratory viruses in primary human lung organoid-derived air-liquid interface cultures

Rinu Sivarajan, Paul C. Kirchgatterer, Jan Lawrenz, Eszter Tanner-Matiz, Jessica Lindenmayer, Verena Renz, Tapan Joshi, Heike Oberwinkler, Thorsten Walles, Giorgio Fois, Alexander Kleger, Manfred Frick, Jan Münch, Moritz M. Gaidt, Maria R. Steinke, Konstantin M. J. Sparrer

The paper demonstrates that tonic interferons are critical for early antiviral defense in human lung organoid-derived air-liquid interface cultures against HRV16.

bioRxiv · Dec 11, 2025 · PreprintMicrobiology

Modeling Endothelial Dysfunction in Idiopathic Pulmonary Fibrosis: Bridging Mechanistic Insights and Translational Applications

Annalena Branz, Irina Shalashova, Anastasia M. Funk, Tarek Gensheimer, Agnieszka Wytyk, Susanne L. Wespel, Jochen Drescher, Christoph H. Mayr, Lavinia Neubert, Jan C. Kamp, Mark Kühnel, Danny David Jonigk, Manfred Frick, Muriel Lizé

This paper identifies PMVEC alterations in IPF using single-cell RNA sequencing and spatial transcriptomics, develops endothelial injury models, and validates functional assays for drug discovery.

bioRxiv · Sep 29, 2025 · PreprintCell Biology

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad-Spectrum 1 Efficacy Against Corona and Influenza Viruses

Jan Lawrenz, Lukas Wettstein, Armando Rodríguez, Rayhane Nchioua, Pascal von Maltitz, Dan Albers, Fabian Zech, Julie Vandeput, Lieve M. J. Naesens, Giorgio Fois, Veronika Neubauer, Nico Preising, Emilia Schmierer, Yasser Almeida‐Hernández, Moritz Petersen, , Jan Münch

This paper identifies Trypstatin, a Kunitz-type protease inhibitor that inhibits TMPRSS2 and related proteases, showing broad-spectrum antiviral activity against SARS-CoV-2, influenza, and other respiratory viruses.

Advanced Science · May 14, 2025Peer-reviewedMicrobiology