Christoph H. Mayr

This paper identifies PMVEC alterations in IPF using single-cell RNA sequencing and spatial transcriptomics, develops endothelial injury models, and validates functional assays for drug discovery.

The paper uses single-cell RNA-seq to analyze aging effects on lung regeneration, identifying immune cell states linked to impaired progenitor function in aged mice.

The paper characterizes compartment-specific proteomic changes in liver fibrosis models and identifies potential therapeutic targets.

This study investigates ligand-specific AXL signaling in IPF, showing GAS6 promotes basal cell proliferation while PROS1 inhibits it, with implications for therapeutic targets.

This study uses single-cell RNA-sequencing to analyze how different nanomaterials affect lung inflammation in mice, identifying cell type-specific responses and mechanisms.

The paper uses spatial transcriptomics to identify novel pathologic niches in IPF lung tissue and their cellular composition and communication.

This study identifies NFATC4 as a regulator of myofibroblast activity through phosphoproteomic analysis of fibroblast mechanosensing on stiffness-modulated substrates.

The paper uses single-cell RNA-seq to identify Krt8+ progenitor cells involved in lung regeneration and shows their role in epithelial differentiation and disease.

The paper maps aging in the lung using single cell transcriptomics and proteomics, identifying novel age-related changes in cell types and the extracellular matrix.