FibrilPaint20 directs the ubiquitin-proteasome system to Tau amyloid fibrils
Françoise A. Dekker, Júlia Aragonès Pedrola, Emile van Weert, Anne den Breejen, Laura Peters, Adriana Poza-Rodriguez, Guy Mayer, Shalini Singh, Alfred C.O. Vertegaal, Assaf Friedler, Stefan Rüdiger
The paper demonstrates that FP20 recruits the ubiquitin-proteasome system to Tau amyloid fibrils, enabling their degradation and offering a strategy for targeting amyloid diseases.
bioRxiv · Aug 27, 2024 · PreprintBiochemistry