Altered endothelial mitochondrial Opa1-related fusion in mouse amplifies age-associated vascular and kidney damages
Carlotta Turnaturi, Loïck L'Hoste, Coralyne Proux, Linda Grimaud, Emilie Vessières, António Zorzano, Anne Teissier, Pascal Reynier, Raffaella Sorrentino, Guy Lenaers, Laurent Loufrani, Daniel Henrion
This study shows that reduced Opa1 in endothelial cells of old mice worsens vascular function and increases kidney oxidative stress.
bioRxiv · Jan 29, 2025 · PreprintPhysiology