António Zorzano

Fasting-induced hepatic gluconeogenesis is compromised in Anxa6-/- mice

This study shows that Anxa6-/- mice have impaired fasting-induced hepatic gluconeogenesis, leading to hypoglycaemia and reliance on lipid oxidation.

Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis

This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.

Altered endothelial mitochondrial Opa1-related fusion in mouse amplifies age-associated vascular and kidney damages

This study shows that reduced Opa1 in endothelial cells of old mice worsens vascular function and increases kidney oxidative stress.

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function

This study shows that Mfn2 in NAc D2-MSNs regulates social dominance and neuronal function, while D1-MSNs show transient effects on competitiveness.

Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis and iron homeostasis

This study shows that Slc7a7 deficiency in mice causes erythropoiesis failure and iron overload, with erythropoietin supplementation as a potential therapy for LPI.

A Comprehensive Reanalysis Of Publicly Available GWAS Datasets Reveals An X Chromosome Rare Regulatory Variant Associated With High Risk For Type 2 Diabetes.

The paper reanalyzes T2D GWAS data to identify a rare X chromosome variant associated with increased T2D risk in males.