N6-methyladenosine regulation of mRNA translation is essential for early human erythropoiesis
Daniel A. Kuppers, Sonali Arora, Cindy L. Wladyka, Ruiqi Ge, Shun Liu, Yong Peng, Rui Jun Su, Anne Wilhite, Jianjun Chen, Chuan He, Andrew Caleb Hsieh, Patrick J. Paddison
This study identifies two critical m6A-regulated developmental windows in human erythropoiesis, showing m6A-MTase activity is essential for proliferation and differentiation in BFU-E and CFU-E.
bioRxiv · Nov 10, 2025 · PreprintDevelopmental Biology