Andrew Caleb Hsieh

Gene expression inference from cell-free DNA using uncertainty-aware deep learning

This paper develops a deep learning framework to infer gene expression from cell-free DNA, improving reliability and enabling functional genomics in precision oncology.

N6-methyladenosine regulation of mRNA translation is essential for early human erythropoiesis

This study identifies two critical m6A-regulated developmental windows in human erythropoiesis, showing m6A-MTase activity is essential for proliferation and differentiation in BFU-E and CFU-E.

Decoding RNA Metabolism by RNA-linked CRISPR Screening in Human Cells

This study uses ReLiC screens to analyze the effects of RNA-associated protein knockouts on RNA metabolism, revealing modular gene network interactions and pathway-specific coupling between growth fitness and mRNA translation.

Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

The paper shows that cells use an adaptive pausing response to survive severe stress by pausing translation and limiting ATP use, followed by recovery through ISR signaling.