Cyclic lipopeptide natural products as taxa-specific antibacterial inhibitors of the lipid II flippase
Elizabeth B Barrois, Jonas Henrique Costa-Martini, Lina Thoma, Justin M. Van Riper, Anne Wochele, Calla Olson, Heike Brötz‐Oesterhelt, Chad W. Johnston
The paper investigates imacidin, a cyclic lipopeptide that inhibits the lipid II flippase MurJ, identifying it as a taxa-specific antibacterial agent with potential for precision antibiotics.
bioRxiv · Oct 2, 2025 · PreprintMicrobiology