Chad W. Johnston

This study identifies lipoprotein-mediated endocytosis as a conserved mechanism for cationic cell-penetrating peptides across animal lineages, showing it modulates their antimicrobial function.

The paper investigates imacidin, a cyclic lipopeptide that inhibits the lipid II flippase MurJ, identifying it as a taxa-specific antibacterial agent with potential for precision antibiotics.

This paper identifies gammanonin, a natural product from Gammaproteobacteria that inhibits bacterial peptide deformylase without the toxic hydroxamate group found in actinonin.

This paper introduces DeepMet, a chemical language model that predicts and discovers unknown metabolites using mass spectrometry data.