Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike
Xiaodi Yu, Jarek Juraszek, Lucy Rutten, Mark J. G. Bakkers, Sven Blokland, Jelle M. Melchers, Niels J. F. van den Broek, Annemiek Verwilligen, Pravien D. Abeywickrema, Johan Vingerhoets, Jean‐Marc Neefs, Shah A. Mohamed Bakhash, Pavitra Roychoudhury, Alexander L. Greninger, Sujata Sharma, Johannes P. M. Langedijk
This study identifies two SARS-CoV-2 variants with NTD deletions that reshape the antigenic surface and reduce antibody binding, highlighting the plasticity of the NTD for immune escape.
PLoS Pathogens · May 1, 2023Peer-reviewedMolecular Biology