Alexander L. Greninger

This study shows H5N5 viruses have been repeatedly introduced across the Atlantic by high latitude seabirds, with more frequent introductions in fall and spring, and a distinct ecology from H5N1.

The paper develops a single-amplicon sequencing method to recover coding-complete genomes of enteroviruses and rhinoviruses from clinical specimens, showing higher fidelity and lower cost than hybridization capture.

This study identifies EIDD-3525 as a broad-spectrum antiviral against alphaviruses that inhibits RNA replication by targeting the nsP4 polymerase.

This study reports neutralization titers from 355 human sera against 148 influenza strains, showing reduced neutralization of new H3N2 and H1N1 variants.

The paper identifies and characterizes a stably integrated Alphatorquevirus genome in the SKNO-1 acute myeloid leukemia cell line, demonstrating its transcriptional maintenance and chromatin accommodation.

This paper reviews six years of clinical HSV acyclovir resistance testing, confirming common resistance mechanisms and identifying 23 novel UL23 mutations.

This paper develops a new antiviral compound, GHP-88310, showing high tolerability and oral efficacy against measles and respiratory paramyxoviruses in animal models.

This study identifies novel small-molecule inhibitors of Chikungunya virus replication through high-throughput screening and characterizes their mechanism of action and resistance profiles.

This study identifies neutralizing epitopes on the measles virus fusion protein by analyzing monoclonal antibodies and their structural interactions with prefusion and postfusion conformations.

This study analyzes Treponema pallidum strains in Buenos Aires, Argentina, using whole genome sequencing and tprK locus analysis to understand transmission dynamics and lineage-specific diversity.

This study recovers Ghana virus, an African bat Henipavirus, and shows it has restricted receptor tropism and attenuated pathogenicity compared to Nipah virus.

This paper describes the discovery of a potent monoclonal antibody, 4F11, that neutralizes HMPV with high efficacy and low resistance potential.

This study identifies mutations in VEEV nsP4 that reduce susceptibility to 4-FlU, shows these mutations do not fully prevent 4-FlU's therapeutic effect in mice, and highlights its potential as an antiviral for alphavirus encephalitis.

The paper shows three T. pallidum isolates with Tp0705 PBP polymorphisms are equally susceptible to penicillin G and ceftriaxone.

This study designs and tests a stabilized full-length measles fusion protein antigen that induces strong neutralizing antibodies and protects against viral challenge in a cotton rat model.

This paper develops an attenuated SARS-CoV-2 virus expressing nanoluciferase to identify and validate drug-resistant mutants to nirmatrelvir without using wild-type virus.

This study shows RSV F evolution can escape some monoclonal antibodies but does not strongly reduce neutralization by human polyclonal sera, and introduces a tool to measure neutralization against RSV strains.

This study introduces two novel amplicon sequencing schemes for RSV A and B, demonstrating their effectiveness in generating high-quality genomes globally and revealing minimal geographic clustering of RSV sequences.

The paper evaluates a tiling amplicon panel for RSV whole genome sequencing, showing high sensitivity, specificity, and accuracy in clinical and contrived samples.

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

The paper quantifies neutralizing antibody responses to influenza strains using sera collected in 2024-2025 to inform vaccine-strain selection for 2025.

The paper develops and validates 12 new VADR models for human respiratory viruses, achieving high accuracy in genome annotation and identifying novel viral biology.

This study evaluates late-onset antiviral treatment in immunocompromised mice with persistent SARS-CoV-2 infection, finding that 4-FlU significantly reduces virus load, while paxlovid causes viral rebound.

The paper introduces genetically encoded fluorescent tags for Treponema pallidum and Sf1Ep cells to enhance visualization and study host-pathogen interactions in syphilis research.

This study shows that long-term in vitro exposure of Treponema pallidum to sub-bactericidal doxycycline does not induce resistance, supporting the use of doxy-PEP for syphilis prevention.

The paper identifies Tp-specific CD4+ T cell responses in blood and skin of syphilis patients, showing persistence after treatment and highlighting potential vaccine targets.

The paper analyzes Treponema pallidum genomic data from Seattle to identify strain circulation and tprK antigen variation patterns in syphilis cases.

This study identifies two SARS-CoV-2 variants with NTD deletions that reshape the antigenic surface and reduce antibody binding, highlighting the plasticity of the NTD for immune escape.

The paper introduces a thermodynamically coupled biosensor to rapidly detect neutralizing antibodies against SARS-CoV-2 strains in serum samples.