Cell BiologybioRxivPreprint
Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability
Jun Wang, Long Liao, Bo Yang…·Cun Wang
This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.
DOI 10.1101/2023.12.22.572948