Interdependent Dynamics of mRNA Expression and HIV-1 Viral Load: Insights from Transcriptomics and Mendelian Randomization
Sergey Oreshkov, Christian Wandall Thorball, Jenny Maylan, Maude Muriset, Alexandra Calmy, Angela Ciuffi, Luigia Elzi, Johannes Nemeth, Ansar Muhammad, Lukas Baumann, Patrick Schmid, M Stöckle, Daniel Alpern, the Swiss HIV Cohort Study, Jacques Fellay, Federico Andrea Santoni
The paper identifies 792 genes associated with HIV load using transcriptomics and confirms TRABD2A as a viral restriction factor through Mendelian Randomization.
bioRxiv · Nov 13, 2025 · PreprintImmunology