Christian Wandall Thorball

Comparative evaluation of genotyping and low-pass sequencing for pharmacogenetic variant and phenotype inference

This study compares genotyping arrays and low-pass whole-genome sequencing for pharmacogenetic variant and phenotype inference, finding high concordance but improved variant coverage with LP-WGS.

Interdependent Dynamics of mRNA Expression and HIV-1 Viral Load: Insights from Transcriptomics and Mendelian Randomization

The paper identifies 792 genes associated with HIV load using transcriptomics and confirms TRABD2A as a viral restriction factor through Mendelian Randomization.

Rare variants in infection response protein pathways associated with sepsis in children.

The paper identifies genetic pathways and variants associated with sepsis susceptibility in children through genomic analysis of a paediatric cohort.

Genome-wide association study of pediatric bacteremia and sepsis

This paper identifies a genetic locus associated with sepsis susceptibility in children using a genome-wide association study of a national cohort.

Genetic features and genomic targets of human KRAB-Zinc Finger Proteins

This study examines the genetic features and genomic targets of human KRAB-Zinc Finger Proteins, revealing their role in regulating transposable elements and their evolutionary significance.

Associations of genetic and infectious risk factors with coronary heart disease

This study identifies high polygenic risk and infection with Fusobacterium nucleatum as independent risk factors for incident coronary heart disease in a population cohort.

A phylogeny-aware GWAS framework to correct for heritable pathogen effects on infectious disease traits

This paper introduces a phylogeny-aware GWAS framework to correct for heritable pathogen effects on infectious disease traits, showing improved detection of host genetic variants in simulations and applied to HIV-1 data.

Ongoing evolution of KRAB zinc finger protein-coding genes in modern humans

The paper analyzes the evolutionary dynamics of KRAB zinc finger protein-coding genes in humans, finding that older genes show stronger negative selection while younger genes exhibit more genetic variation and less constraint.

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma

This study identifies a genetic variant near CXCL12 associated with increased susceptibility to HIV-related non-Hodgkin lymphoma.

Genetic factors and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

This study identifies age, sex, and genetic variants as key predictors of variability in humoral immune responses to pathogens and vaccines.

A genome-wide polygenic approach to HIV uncovers link to inflammatory bowel disease and identifies potential novel genetic variants

The paper uses polygenic methods to identify genetic overlaps between HIV acquisition and schizophrenia, ulcerative colitis, and finds potential novel variants associated with HIV.