Daniel Alpern

Growth factor-free synthetic matrices reveal intrinsic skeletal progenitor competence

This study shows that growth factor-free synthetic matrices reveal donor-specific differences in human skeletal progenitor cell osteogenic potential, which are masked by conventional methods.

Interdependent Dynamics of mRNA Expression and HIV-1 Viral Load: Insights from Transcriptomics and Mendelian Randomization

The paper identifies 792 genes associated with HIV load using transcriptomics and confirms TRABD2A as a viral restriction factor through Mendelian Randomization.

Transcriptomic profiling of murine GnRH neurons reveals developmental trajectories linked to human reproduction

This study profiles GnRH neurons in mice to uncover developmental gene expression patterns linked to human reproductive processes.

Neuro-toxicogenomic mapping of TMT induced neurotoxicity using human minibrain reveals associated adverse outcome events

This study uses human minibrain models and BRB-seq to analyze TMT-induced neurotoxicity, identifying key molecular events and pathways involved in adverse outcomes.

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

This study identifies the Hippo pathway's role in regulating sarcomeric gene expression to control myofibril assembly and muscle fiber growth in Drosophila.

Time- and cost-efficient high-throughput transcriptomics enabled by Bulk RNA Barcoding and sequencing

This paper introduces BRB-seq, a cost-effective bulk RNA-seq method that matches TruSeq performance and enables high-throughput transcriptomics with low-quality RNA.