Reconstitution of Arp2/3-Nucleated Actin Assembly with CP, V-1 and CARMIL
Olivia L. Mooren, Patrick McConnell, James D. DeBrecht, Anshuman Jaysingh, John A. Cooper
The paper investigates whether CPI-motif proteins activate or inhibit Arp2/3-mediated actin assembly by reconstituting the system with purified components and finds that CARMIL promotes actin assembly by counteracting V-1 inhibition.
bioRxiv · May 13, 2024Cell Biology