A population genomics approach to assessing the genetic basis of within-host microevolution underlying recurrent cryptococcal meningitis infection
Johanna L. Rhodes, Mathew A. Beale, Mathieu Vanhove, Joseph N Jarvis, Shichina Kannambath, John Alastair Simpson, Anthea Ryan, Graeme Meintjes, Thomas Stephen Harrison, Matthew C. Fisher, Tihana A. Bicanic
The paper uses whole-genome sequencing to determine whether recurrent cryptococcal meningitis in HIV patients results from relapse or reinfection, finding clonal relationships in most cases and novel hypermutator mechanisms in others.
G3 Genes Genomes Genetics · Feb 10, 2017Peer-reviewedGenomics