Shichina Kannambath

In vitro host transcriptomics during Cryptococcus neoformans, Cryptococcus gattii, and Candida albicans infection of South African volunteers

The paper compares the transcriptional responses of immune cells to three fungal pathogens in vitro, finding distinct expression patterns and a weaker response to cryptococcal stimuli.

Single cell transcriptomic and spatial landscapes of the developing human pancreas

This study integrates single-cell RNA sequencing and spatial transcriptomics to map the temporal-spatial gene expression patterns during human pancreas development, identifying lineage dynamics and novel genes involved in beta cell maturation.

A population genomics approach to assessing the genetic basis of within-host microevolution underlying recurrent cryptococcal meningitis infection

The paper uses whole-genome sequencing to determine whether recurrent cryptococcal meningitis in HIV patients results from relapse or reinfection, finding clonal relationships in most cases and novel hypermutator mechanisms in others.