Mechanistic Insights into Alcohol-Induced DNA Crosslink Repair by the Fanconi Anemia Nuclease Slx4-Xpf-Ercc1
Jana Havlikova, Milan Dejmek, Andrea Hušková, Anthony Allan, Evžen Bouřa, Radim Nencka, Jan Šilhán
This study identifies the role of the SLX4-XPF-ERCC1 nuclease complex in repairing alcohol-induced DNA crosslinks by making two precise incisions around the lesion.
Communications Biology · Sep 26, 2025Peer-reviewedBiochemistry