Radim Nencka

The paper functionally and structurally characterizes RNA cap methyltransferases from Trichomonas vaginalis and identifies inhibitors targeting these enzymes.

The paper develops branched C7-substituted 7-deaza-SAH analogues that inhibit mpox virus VP39 and dengue virus NS5 methyltransferases by occupying their SAM-binding pockets.

This study identifies the role of the SLX4-XPF-ERCC1 nuclease complex in repairing alcohol-induced DNA crosslinks by making two precise incisions around the lesion.

This study designs and synthesizes fluorinated cGAMP analogs that are stable against poxin cleavage and show high STING activation, with structural insights into their binding modes.

The paper solves the crystal structure of the SARS-CoV-2 nsp10-nsp16 MTase complex and models its interaction with RNA, revealing low conservation with Zika MTase and implications for inhibitor design.