Iterative structural homology search identifies new substrates of the protein O-fucosyltransferases POFUT3 and POFUT4
Benjamin M. Eberand, Huilin Hao, Michelle Cielesh, Kiran Muthukrishnan, Lucas Kambanis, Anthony Ayoub, Yvonne Kong, Jemma Fenwick, Leonie Heilbronn, Richard J. Payne, Freda H. Passam, Robert S. Haltiwanger, Mark Larance
The paper identifies new substrates of POFUT3 and POFUT4 using structural homology searches, showing MFAP2/MFAP5 are O-fucosylated and require POFUT3 for secretion.
bioRxiv · May 15, 2026 · PreprintBiochemistry